Twenty year experience of the oral rabies vaccine SAG2 in wildlife: a global review.
Identifieur interne : 000098 ( Main/Exploration ); précédent : 000097; suivant : 000099Twenty year experience of the oral rabies vaccine SAG2 in wildlife: a global review.
Auteurs : Philippe M Hl [France] ; Florence Cliquet [France] ; Anne-Laure Guiot [France] ; Enel Niin [Estonie] ; Emma Fournials [France] ; Nathalie Saint-Jean [France] ; Michel Aubert [France] ; Charles E. Rupprecht [Oman] ; Sylvie Gueguen [France]Source :
- Veterinary research [ 1297-9716 ] ; 2014.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Disease Eradication, Europe, Foxes, Rabies (prevention & control), Rabies (veterinary), Rabies Vaccines (administration & dosage), Rabies Vaccines (genetics), Rabies Vaccines (standards), Rabies virus (physiology), Raccoon Dogs, Vaccination (veterinary), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics).
- MESH :
- chemical , administration & dosage : Rabies Vaccines, Vaccines, Attenuated.
- chemical , genetics : Rabies Vaccines, Vaccines, Attenuated.
- chemical , standards : Rabies Vaccines.
- geographic : Europe.
- physiology : Rabies virus.
- prevention & control : Rabies.
- veterinary : Rabies, Vaccination.
- Administration, Oral, Animals, Disease Eradication, Foxes, Raccoon Dogs.
Abstract
The SAG2 vaccine (RABIGEN® SAG2) is a modified live attenuated rabies virus vaccine, selected from the SAD Bern strain in a two-step process of amino acid mutation using neutralizing monoclonal antibodies. The strain is genetically stable and does not spread in vivo or induce a persistent infection. Its absence of residual pathogenicity was extensively demonstrated in multiple target and non target species (such as wild carnivores and rodent species), including non-human primates. The efficacy of SAG2 baits was demonstrated according to the EU requirements for the red fox and raccoon dog. The use of safe and potent rabies vaccines such as SAG2 largely contributed to the elimination of rabies in Estonia, France, Italy and Switzerland. Importantly, these countries were declared free of rabies after few years of oral vaccination campaigns with SAG2 baits distributed with an appropriate strategy. The excellent tolerance of the SAG2 vaccine has been confirmed in the field since its first use in 1993. No safety issues have been reported, and in particular no vaccine-induced rabies cases were diagnosed, after the distribution of more than 20 million SAG2 baits in Europe.
DOI: 10.1186/s13567-014-0077-8
PubMed: 25106552
Affiliations:
- Estonie, France, Oman
- Auvergne-Rhône-Alpes, Provence-Alpes-Côte d'Azur, Rhône-Alpes
- Callian, Carros, Lyon
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Le document en format XML
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Hl, Philippe" uniqKey="M Hl P" first="Philippe" last="M Hl">Philippe M Hl</name><affiliation wicri:level="3"><nlm:affiliation>Virbac, 13ème Rue LID, BP 27, 06511, Carros Cedex, France. pmahl@virbac.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Virbac, 13ème Rue LID, BP 27, 06511, Carros Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Carros</settlement></placeName></affiliation></author><author><name sortKey="Cliquet, Florence" sort="Cliquet, Florence" uniqKey="Cliquet F" first="Florence" last="Cliquet">Florence Cliquet</name><affiliation wicri:level="1"><nlm:affiliation>Anses, Laboratory for Rabies and Wildlife, European Union Reference Laboratory for rabies, European Union Reference Laboratory for rabies serology, OIE Reference Laboratory for rabies, WHO Collaborating Centre on Research and Management on Zoonoses Control, Technopôle agricole et veterinaire, CS 40009, 54220, 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The strain is genetically stable and does not spread in vivo or induce a persistent infection. Its absence of residual pathogenicity was extensively demonstrated in multiple target and non target species (such as wild carnivores and rodent species), including non-human primates. The efficacy of SAG2 baits was demonstrated according to the EU requirements for the red fox and raccoon dog. The use of safe and potent rabies vaccines such as SAG2 largely contributed to the elimination of rabies in Estonia, France, Italy and Switzerland. Importantly, these countries were declared free of rabies after few years of oral vaccination campaigns with SAG2 baits distributed with an appropriate strategy. The excellent tolerance of the SAG2 vaccine has been confirmed in the field since its first use in 1993. No safety issues have been reported, and in particular no vaccine-induced rabies cases were diagnosed, after the distribution of more than 20 million SAG2 baits in Europe.</div></front></TEI><affiliations><list><country><li>Estonie</li><li>France</li><li>Oman</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhône-Alpes</li></region><settlement><li>Callian</li><li>Carros</li><li>Lyon</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="M Hl, Philippe" sort="M Hl, Philippe" uniqKey="M Hl P" first="Philippe" last="M Hl">Philippe M Hl</name></region><name sortKey="Aubert, Michel" sort="Aubert, Michel" uniqKey="Aubert M" first="Michel" last="Aubert">Michel Aubert</name><name sortKey="Cliquet, Florence" sort="Cliquet, Florence" uniqKey="Cliquet F" first="Florence" last="Cliquet">Florence Cliquet</name><name sortKey="Fournials, Emma" sort="Fournials, Emma" uniqKey="Fournials E" first="Emma" last="Fournials">Emma Fournials</name><name sortKey="Gueguen, Sylvie" sort="Gueguen, Sylvie" uniqKey="Gueguen S" first="Sylvie" last="Gueguen">Sylvie Gueguen</name><name sortKey="Guiot, Anne Laure" sort="Guiot, Anne Laure" uniqKey="Guiot A" first="Anne-Laure" last="Guiot">Anne-Laure Guiot</name><name sortKey="Saint Jean, Nathalie" sort="Saint Jean, Nathalie" uniqKey="Saint Jean N" first="Nathalie" last="Saint-Jean">Nathalie Saint-Jean</name></country><country name="Estonie"><noRegion><name sortKey="Niin, Enel" sort="Niin, Enel" uniqKey="Niin E" first="Enel" last="Niin">Enel Niin</name></noRegion></country><country name="Oman"><noRegion><name sortKey="Rupprecht, Charles E" sort="Rupprecht, Charles E" uniqKey="Rupprecht C" first="Charles E" last="Rupprecht">Charles E. 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